Prepare the Oven and Pan: Preheat your oven to 350°F (175°C) and grease a 9x5 inch loaf pan to prevent sticking.
Mix Dry Ingredients: In a large bowl, whisk together the flour, sugar, baking powder, baking soda, and salt until well combined.
Combine Wet Ingredients: In a separate bowl, whisk together the melted butter, eggs, buttermilk, and vanilla extract until smooth.
Form the Batter: Gradually add the wet ingredients to the dry ingredients, stirring gently until just combined (avoid overmixing).
Add Pecans: Fold in the chopped pecans evenly throughout the batter.
Bake the Bread: Pour the batter into the prepared loaf pan and spread it evenly. Bake in the preheated oven for 50-60 minutes, or until a toothpick inserted in the center comes out clean.
Cool and Serve: Allow the bread to cool in the pan for 10 minutes, then transfer to a wire rack to cool completely. Slice and enjoy with a cup of coffee or tea!